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Antimicrobial Activity and Molecular Docking Studies of Some Novel Tetrazolo Diazepine Derivatives

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Author(s): Helen P. Kavitha1*, Samiappan Sathish kumar1 and Ramachandran Balajee2

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2946;
Date: 2011;
Original page

Keywords: Diazepine derivatives | Antibacterial activity | Antifungal activity | Molecular docking | NKG2D receptor.

ABSTRACT
Inspired by the biological importance of tetrazole and diazepam moieties, seven novel tetrazolo diazepine derivatives ( 4a - 4g) were synthesized. The synthesizedcompounds were screened for antibacterial activity against human pathogens such as E. coli, S. aureus, P. aeruginosa, plant pathogens such as Pseudomoas,Rhodococcus, Ralstonia, Xanthomonas (from tomato) and Xanthomonas (from carrat) and antifungal activity against C. albicans, A. niger, Penicillium, A.fumigatus. Molecular docking studies were carried out against NKG2D immunoreceptor using arguslab and autodock tools. Out of the seven derivatives, compound4d is found to have better docking score when docked against NKG2D receptor.
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