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Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes

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Author(s): Hakan Arslan | Nizami Duran | Gulay Borekci | Cemal Koray Ozer | Cevdet Akbay

Journal: Molecules
ISSN 1420-3049

Volume: 14;
Issue: 1;
Start page: 519;
Date: 2009;
Original page

Keywords: Thiourea derivatives | Complexes | Antibacterial activity | Antifungal activity | In vitro studies | Lipophilicity

ABSTRACT
Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.
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