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Antimicrobial and cytotoxic activities of 2-aminobenzoic acid and 2-aminophenol and their coordination complexes with Magnesium (Mg-II)

Author(s): S. Sarkar | M. Akhter Farooque

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 7;
Issue: 1;
Start page: 25;
Date: 2004;
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Keywords: Coordination complexes | antimicrobial activity | antifungal activity | cytotoxicity

Owing to the biological importance of metalloelements in many biological processes, especially metabolic processes, magnesium(II) complexes were synthesized and examined for their antimicrobial and cytotoxic activities. Among the two synthesized organometalic complexes [Mg(2-ap)2, A] and [Mg(2-ab)2, C], the maximum antibacterial and antifungal activities were shown by the compound A. Among the ligands, 2-aminophenol (B) showed more antibacterial activity than 2-aminobenzoic acid (D). The minimum inhibitory concentration for the complex A against five pathogenic bacteria Streptococcus-haemolyticus, Bacillus subtilis, Staphylococcus aureus, Salmonella typhi and Escherichia coli were found in the range of 32-64 μg ml-1. The complexes were also tested for their cytotoxicity using brine shrimp lethality bioassay method and the LC50 values of the complexes A and C were found to be 5.7 and 24.3 µg ml-1 respectively. Antibacterial, antifungal and cytotoxic studies undertaken for the above compounds indicated structure-activity relationships. These metalloderivatives were more active than the parent compounds (ligands).
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