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Antioxidant Activity of Eclipta alba L. in Normal Rat Liver

Author(s): A. Sandeep Majumdar | M. Natvarlal Saraf | R. Yadav Kamble

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 9;
Issue: 2;
Start page: 103;
Date: 2010;
Original page

Keywords: SOD | CAT | GPx | GR

The present study investigates the antioxidant potential of the ethyl acetate fraction of the aerial parts Eclipta alba L. Hassk (EAEA) which was widely used as hepatoprotective plant. EAEA was orally administered at doses of 50, 100 and 200 mg/kg for 7 days in male Charles Foster rats. The extent of hepatoprotective potential of E. alba was studied by assessing the biochemical parameters like lipid peroxides (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), ascorbic acid and α-tocopherol in the liver of rats. Oral administration of the EAEA significantly decrease LPO and elevated the activity of antioxidant enzymes SOD, CAT, GPx and GR as well as endogenous levels of ascorbic acid and α-tocopherol in the liver of male Charles Foster rats. This study has revealed the significant antioxidant potential of E. alba in rat liver.

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