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ANTIOXIDANT ACTIVITY OF ETHANOLIC ROOT EXTRACT OF ANACYCLUS PYRETHRUM

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Author(s): K.Sujith | C. Ronald Darwin | V.Suba

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 12;
Start page: 222;
Date: 2011;
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Keywords: Anacyclus pyrethrum | antioxidant | flavonoids | lipid peroxidation | scavenging activity.

ABSTRACT
The ethanolic extract of Anacyclus pyrethrum root was screened for invitro and exvivo antioxidant activities by using different experimental models .Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging neurodegenerative diseases and carcinogenesis .Antioxidant activity of ethanolic extract of Anacyclus pyrethrum root were assessed using DPPH, hydroxyl, hydrogen peroxide ,determination of reducing power ,nitric oxide in vitro scavenging models and ex vivo models such as assay on lipid peroxidation using rat brain homogenate .The extract were also studied for total phenolic, flavonoids ,and ascorbic acid compounds content .The ethanolic extract of Anacyclus pyrethrum root exhibited significant scavenging activity in DPPH, hydroxyl, hydrogen peroxide, nitric oxide in vitro scavenging models.The reducing power of the extract increased in dose dependant manner and the extract also showed marked protection in lipid peroxidation The ethanolic extract of Anacyclus pyrethrum root shows significant antioxidant activity in different in vitro and ex vivo models. The antioxidant potential of the Anacyclus pyrethrum root extract may due to their photochemical constituents such as phenols, flavonoids, alkaloids, tannins. Thus augmenting the wide use of plant in the indigenous system of medicine for free radical mediated disease.
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