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ANTIOXIDANT ACTIVITY OF GARCINIA GUMMI GUTTA (LINN) IN PARACETAMOL INTOXICATED WISTAR ALBINO RATS

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Author(s): Thamizh Selvam N | Anjusha P | Sanjaya Kumar YR | Salini Chandran K | Venugopalan TN

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 11;
Start page: 116;
Date: 2011;
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Keywords: antioxidant activity | Garcinia gummi gutta | Glutathione | SOD | Peroxidase

ABSTRACT
The study was carried out to determine antioxidant activity of methanolic extract of Garcinia gummi gutta fruit in the selective in vivo model system using Wistar albino rats. The experiment was comprised of five groups such as Healthy control, Disease control (Paracetamol treated), Positive control (Silymarin treated), test groups G. gutta lower dose(250mg/kg b.wt) and higher dose (500 mg/kg b.wt). The study period was 10 days and the biochemical profile including SGOT, ALKP, Total protein and antioxidant enzymes Superoxide dismutase, Glutathione peroxidase and Glutathione reductase levels were evaluated in blood and tissue samples (liver, kidney, heart) of all the experimental animals. The study proved that there was a significant improvement of antioxidant enzyme levels in the G. gutta treated groups as compared to the control groups and the efficacy was found to be dose dependent. The study proved the antioxidant activity of G. gutta extract and further study on characterization of phytoconstituents is under progress for harnessing G. gutta as a drug formulation.

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