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ANTIOXIDANT ACTIVITY OF MAJORANA HORTENSIS LEAVES SUBJECTED TO OXIDATIVE STRESS IN AN IN VITRO SYSTEM

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Author(s): Palaniswamy Radha | Padma P.R.

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 6;
Start page: 153;
Date: 2011;
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Keywords: antioxidants | oxidant | free radicals | reactive oxygen species | oxidative stress.

ABSTRACT
Oxidative stress can arise from an imbalance between the generation and elimination of reactive oxygen species leading to the excess levels, which in turn cause various diseases and cell death. Reactive oxygen species can be eliminated by a number of enzymic and non-enzymic antioxidant defense mechanisms. This was studied in Majorana hortensis using in vitro model simulating the in vivo system. Precision-cut goat liver slices were challenged with a standard oxidant (H2O2) both in the presence and in the absence of the different extracts of the leaves. The enzymic and non-enzymic antioxidants were analyzed in the homogenate of the liver slices after incubation. The oxidant treated liver slices showed a decrease in the levels of antioxidants compared to the untreated control. But in the presence of the leaf extracts, the antioxidant status was reverted back to a significant extent. Thus, the results showed that the leaf extracts of the candidate plant can improve the antioxidant status in the goat liver slices exposed in vitro to oxidative stress.
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