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The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

Author(s): Kang In Choe | Joo Hee Kwon | Kwan Hee Park | Myeong Hwan Oh | Manh Heun Kim | Han Hyuk Kim | Su Hyun Cho | Eun Kyung Chung | Sung Yi Ha | Min Won Lee

Journal: Molecules
ISSN 1420-3049

Volume: 17;
Issue: 10;
Start page: 11484;
Date: 2012;
Original page

Keywords: Rhodiola sachalinensis | antioxidants | radical scavengers | Nitric oxide | HPLC

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.
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