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Antioxidant and Blood Brain Barrier Status in Cerebrospinal Fluid of Bacterial Meningitis Rat Model after Vancoplus Treatment

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Author(s): A. Soni | V.K. Dwivedi | M. Chaudhary | S.M. Shrivastava

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 9;
Issue: 4;
Start page: 194;
Date: 2009;
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Keywords: Meningitis | methicillin-resistant Saphylococcus aureus | ceftriaxone plus vancomycin | blood brain barrier | antioxidant

ABSTRACT
The aim of this study was to compare the efficacy of ceftriaxone, vancomycin and its fixed dose combination of ceftriaxone plus vancomycin (Vancoplus) for the treatment of meningitis induced by methicillin-resistant Staphylococcus aureus (MRSA) in rat model. The MRSA strain ATCC 43300 was used to induce meningitis in rat model. The rats were fed standard pelleted diet and water ad libitum. Thirty rats were divided into five groups containing six rats in each group. The vancomycin group received 14.2 mg kg-1 b.wt./day, the ceftriaxone group received 28.57 mg kg-1 b.wt./day, the vancoplus group received 42.8 mg kg-1 b.w./day, control and infected group received normal saline. Present findings showed that activities of antioxidant enzymes such as superoxide dismutase and catalase were significantly increased (p
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