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ANTIOXIDANT ENZYME LEVELS AS MARKERS FOR TYPE 2 DIABETES MELLITUS

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Author(s): Sushma Verma, Nibha Sagar, Pushpank Vats, KN Shukla, Mohammad Abbas, Monisha Banerjee*

Journal: International Journal of Bioassays
ISSN 2278-778X

Volume: 2;
Issue: 4;
Start page: 685;
Date: 2013;
Original page

Keywords: Type 2 Diabetes mellitus | Antioxidant enzymes | Oxidative stress | Catalase | Superoxide dismutase | Glutathione S transferase

ABSTRACT
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by increased production of free radicals and oxidative stress. Oxidative stress can be defined as an imbalance between the removal of free radical production and altered activity levels of antioxidant enzymes. The aim of this study was to evaluate the antioxidant enzyme activity such as superoxide dismutase (SOD), catalase (CAT) and glutathione S transferase (GST) in T2DM patients and healthy subjects in a North Indian population. The study was conducted on 474 T2DM and 301 healthy subjects. Blood lysates were prepared and levels of antioxidant enzymes viz. SOD, CAT and GST were measured by spectrophotometric method. Data were analyzed by using Prism software (v 5.01) and expressed as Mean ± SE. The activity levels of SOD and GST were significantly lower in T2DM patients than in healthy subjects (P
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