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Antioxidant and hepatoprotective effect of the roots of Hibiscus esculentus Linn.

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Author(s): Sunilson J | Jayaraj P | Mohan M | Kumari A | Varatharajan R

Journal: International Journal of Green Pharmacy
ISSN 0973-8258

Volume: 2;
Issue: 4;
Start page: 200;
Date: 2008;
Original page

Keywords: Hibiscus esculentus Linn | ethanolic extract | antioxidant activity | hepatoprotective effect

ABSTRACT
The ethanol extract of Hibiscus esculentus Linn roots inhibited the formation of oxygen derived free radicals invitro with IC 50 of 620 µg/ml, 2300 µg/ml, 870 µg/ml and 610 µg/ml. [Fe 2+ /ascobate system], 730 µg/ml, [Fe 3+ /ADP/ascorbate system], for superoxide radical production, hydroxyl radical generation, nitric oxide radical formation and lipid peroxide formation respectively. The oral administration of the extract (250 and 500 mg/kg body weight), significantly reduce CCl 4 induced hepatotoxicity in rats, as judged from the serum and tissue activity of marker enzymes [Glutamate oxaloacetate transaminase (GOT), Glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP)]. These results were comparable with standard drug silymarin [20 mg/kg, P.O.)
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