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Antioxidant and hepatoprotective effects of Clitoria ternatea leaf extracts by using in vivo model

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Author(s): A. JAYACHITRA | S. SREELATHA | P.R. PADMA

Journal: International Journal of Medicinal and Aromatic Plants
ISSN 2249-4340

Volume: 2;
Issue: 2;
Start page: 323;
Date: 2012;
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Keywords: Antioxidants | Clitoria ternatea | free radical | in vivo

ABSTRACT
Herbal medicines are in great demand because of their great efficacy and little or no side effects. Many plant extracts show promising antioxidant and free radical scavenging activity. The plant used in the present study is Clitoria ternatea (Sanskrit-Sankupushpam) belongs to the family Fabaceae. The in vivo studies were conducted using male Wistar rats. Liver cells participate in a variety of metabolic activities and contain a host of enzymes. CCl4 is a known hepatotoxin whose action is mediated by the cytochrome P450 (CYP), the extent of liver damage caused by ethanol-CCl4 treatment was studied by estimating the serum marker enzymes and the circulating lipid profile. The effect of leaf extracts was significantly higher in all the antioxidants suggests Clitoria ternatea a strong protection against oxidative damage in CCl4 induced hepatotoxicity in rats. The observations made in vivo were also confirmed by histopathological studies
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