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Antioxidant and Hepatoprotective Potential of Isolated Fraction of Revia hypocrateriformis

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Author(s): S.S. Saboo | G.G. Tapadiya | S.S. Khadabadi

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 11;
Issue: 6;
Start page: 428;
Date: 2011;
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Keywords: Antioxidant | hepatoprotective | gallic acid | lupeol | HPLC

ABSTRACT
Successive Ethanolic Extracts (SEE) of Rivea hypocrateriformis (RH) which recorded highest polyphenolic contents was subjected to fractionation by column chromatography. All fractions were tested for in vitro antioxidant activity. Out of these fractions, SEE2 possessed significant antioxidant activity. This fraction was further tested for in vivo antioxidant and hepatotoxicity in rat liver using carbon tetrachloride (CCl4), showed significant activity. Further, this claim was confirmed by pretreatment of mice with SEE2 shortened the duration of pentobarbitone induced necrosis. The HPLC analysis was performed for same fraction evidenced the presence of gallic acid and lupeol along with other polyphenol when compared with markers.
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