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Antioxidant Status of Bilirubin and Uric Acid in Patients Diagnosed with Plasmodium falciparum Malaria in Douala

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Author(s): Kouam Eric Bertrand | Ndomou Mathieu | Gouado Inocent | Fotso Kuate Honore

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 11;
Issue: 12;
Start page: 1646;
Date: 2008;
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Keywords: Antioxidant | bilirubin | uric acid | oxidative stress | malaria

ABSTRACT
Oxidative stress and changes in antioxidant status have been implicated in the pathogenesis of malaria. To assess the antioxidant level of bilirubin and uric acid associated with falciparum malaria infection, 60 untreated patients (30 men and 30 women) in Douala, Cameroon were screened for the study. Sixty five healthy individuals (29 men and 36 women) were used as controls. Total and conjugated bilirubin were calculated using Jendrassik-Grof method while uric acid was determined using Barham-Trinder method. It was observed that total and conjugated bilirubins were significantly (p

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