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Antioxidant status and oxidative DNA damage of Bangladeshi dockyard laborers

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Author(s): Muhammad Shahdaat Bin Sayeed1, Sayema Khanum2, Khadija Tul-Kubra3, Md. Ashik Ullah2, Jakir Ahmed Chowdhury4, Mohammad Abul Kalam Azad4, Md. Israt Rayhan5, Mohammad Arif6, Farida Begum2, Abul Hasnat2*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3271;
Date: 2011;
Original page

Keywords: Antioxidant | malondialdehyde | comet assay | dockyard laborers

ABSTRACT
Dockyard laborers are exposed to a variety of genotoxic compounds including heavy metals, polycyclic aromatic hydrocarbons (PAHs), noise, airborne particlesetc. But no specific information is available regarding the effect of exposure to occupational hazards of this group of laborers in Bangladesh. Lipid peroxidation,plasma antioxidant vitamins level (retinol, a-tocopherol and ascorbic acid) and extent of DNA damage were analyzed in 100 dockyard laborers and compared with100 control day laborers having similar socioeconomic status but not exposed to occupational hazards like dockyard laborers. The plasma MDA level as well asextent of DNA damage were significantly higher whereas the plasma retinol and ascorbic acid levels were significantly lower in dockyard laborers than the controlgroup (p0.05). These results illustrate that dockyard laborers are exposed togenotoxic substances resulting in higher oxidative stress.
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