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Antioxidation and Hypomethylation Effects on Genotoxicity and Programmed Cell Death Induced in Mice Somatic Cells by Arsenic Trioxide

Author(s): Saad Alkahtani

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 9;
Issue: 7;
Start page: 721;
Date: 2009;
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Keywords: Methylation | genotoxicity | cytotoxicity | CAs | apoptosis | mice

The present study aims to evaluate the effect of antioxidation and hypomethylation on the genotoxicity and apoptosis induced in mice by arsenic trioxide (As2O3) in normal adult male SWR/J mouse. Animals were treated with intraperitoneally (ip) injected with (2.65, 5.35 or 10.70 mg kg-1 b.wt. of As2O3 which represent 0.25, 0.50 or 1 of LD50, respectively) and killed 24 h later. Another groups were treated with 30 mg kg-1 b.wt. of antioxidant and hypermethylizing agent butylated hydroxy toluene (BHT) 1 h prior to As2O3 administration. Another different groups were treated with three doses of 5-azacitidine (5-AzaC) 5 mg kg -1 b.wt. As2O3 administered after 6 days of the last dose. The three single doses of As2O3 significantly (p
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