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Antioxidation and Hypomethylation Effects on Genotoxicity and Programmed Cell Death Induced in Mice Somatic Cells by Arsenic Trioxide

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Author(s): Saad Alkahtani

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 9;
Issue: 7;
Start page: 721;
Date: 2009;
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Keywords: Methylation | genotoxicity | cytotoxicity | CAs | apoptosis | mice

ABSTRACT
The present study aims to evaluate the effect of antioxidation and hypomethylation on the genotoxicity and apoptosis induced in mice by arsenic trioxide (As2O3) in normal adult male SWR/J mouse. Animals were treated with intraperitoneally (ip) injected with (2.65, 5.35 or 10.70 mg kg-1 b.wt. of As2O3 which represent 0.25, 0.50 or 1 of LD50, respectively) and killed 24 h later. Another groups were treated with 30 mg kg-1 b.wt. of antioxidant and hypermethylizing agent butylated hydroxy toluene (BHT) 1 h prior to As2O3 administration. Another different groups were treated with three doses of 5-azacitidine (5-AzaC) 5 mg kg -1 b.wt. As2O3 administered after 6 days of the last dose. The three single doses of As2O3 significantly (p
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