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The Antioxidative Property of Nitroglycerin Enhances Lornoxicam’s Antiinflammatory Effect

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Author(s): Dr. Selda Sen

Journal: Journal of Anesthesia & Clinical Research
ISSN 2155-6148

Volume: 2;
Issue: 30;
Date: 2011;
Original page

Keywords: Nociception | NSAIDs | Lornoxicam | Nitroglycerin | Nitric oxide | Antioxidative enzymes

ABSTRACT
Background and objectives: The aim of the study is to evaluate the effect of combination of nitroglycerin and lornoxicam on nociception and antioxidative system in rats. Methods: Thirty-nine Wistar male rats were divided into five groups; control group (Group C, n=7), isotonic group (0.09 sodium chloride, Group ISO, n=8 ), lornoxicam group (lornoxicam 1.3 mg kg-1, Group L, n=8), nitroglycerin group (nitroglycerin 1 mg kg-1, Group N, n=8), and lornoxicam-nitroglycerin combination group (1.3 mg kg-1 lornoxicam+1 mg kg-1 nitroglycerin Group L+N, n=8). Hot plate test was applied in all groups before and at 30, 60, 90 minutes after drug injections by intraperitoneal route. Malondialdehyde, nitric oxide, glutathione, and catalase concentrations were measured before and after 90 minutes of drug injection in all blood samples. Results: The latency response of hot plate test was increased in Group L+N at 30 minutes, and Group L and Group L+N at 60 and 90 minutes (p

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