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Antistreptolysin O titer in health and disease: levels and significance

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Author(s): Alyaa Amal Kotby | Nevin Mamdouh Habeeb | Sahar Ezz El Arab

Journal: Pediatric Reports
ISSN 2036-749X

Volume: 4;
Issue: 1;
Start page: e8;
Date: 2012;
Original page

Keywords: antistreptolysin O titer | rheumatic fever

ABSTRACT
Over diagnosis of acute rheumatic fever (ARF) based on a raised antistreptolysin O titer (ASOT) is not uncommon in endemic areas. In this study, 660 children (aged 9.2 ±1.7 years) were recruited consecutively and classified as: G1 (control group, n=200 healthy children), G2 (n=20 with ARF 1st attack), G3 (n=40 with recurrent ARF), G4 (n=100 with rheumatic heart disease (RHD) on long acting penicillin (LAP)), G5 (n=100 with acute follicular tonsillitis), and G6 (n=200 healthy children with history of repeated follicular tonsillitis more than three times a year). Serum ASOT was measured by latex agglutination. Upper limit of normal (ULN) ASOT (80th percentile) was 400 IU in G1, 200 IU in G4, and 1600 IU in G6. Significantly high levels were seen in ARF 1st attack when compared to groups 1 and 5 (P
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