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Antitubercular evaluation of some newer 3-Arylidene-5-(substituted phenyl)-2(3H)-furanones

Author(s): Asif Husaina*, M. M. Alama, M. S. Yara, Aftab Ahmadb

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3303;
Date: 2011;
Original page

Keywords: Furanones | synthesis | mycobacteria | tuberculosis.

A series of 3-Arylidene-5-(substituted phenyl)-2(3H)-furanones (3a-p) was synthesized by the reaction between 3-(substituted benzoyl)propionic acids (1,2) withappropriate aromatic aldehyde in acetic anhydride in presence of triethylamine and were tested for their in vitro antitubercular activity against Mycobacteriumtuberculosis H37Rv (ATCC 27294) in BACTEC medium using the Microplate Alamar Blue Assay (MABA). Among the synthesized compounds, compound (3p) 3-(4-acetoxy-3-methoxybenzylidene-5-(4-bromophenyl)-2(3H)-furanone was found to be the most active agent against Mycobacterium tuberculosis H37Rv withIC90 and IC50 values of 7.85μg/mL and 5.05 μg/mL, respectively.
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Tango Jona
Tangokurs Rapperswil-Jona