Academic Journals Database
Disseminating quality controlled scientific knowledge

Antitumor Compounds from Marine Actinomycetes

ADD TO MY LIST
 
Author(s): Carlos Olano | Carmen Méndez | José A. Salas

Journal: Marine Drugs
ISSN 1660-3397

Volume: 7;
Issue: 2;
Start page: 210;
Date: 2009;
Original page

Keywords: anthracycline | indolocarbazole | macrolide | non-ribosomal peptide synthetase | polyketide synthase

ABSTRACT
Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting tumor-induced angiogenesis. Marine organisms have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?