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Antitumor Compounds from Marine Actinomycetes

Author(s): Carlos Olano | Carmen Méndez | José A. Salas

Journal: Marine Drugs
ISSN 1660-3397

Volume: 7;
Issue: 2;
Start page: 210;
Date: 2009;
Original page

Keywords: anthracycline | indolocarbazole | macrolide | non-ribosomal peptide synthetase | polyketide synthase

Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting tumor-induced angiogenesis. Marine organisms have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.

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