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The Antiulcer Activities of the Methanol Extract of Cassia singueana Leaves Using Indomethacin-Induced Gastric Ulcer Model in Rats

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Author(s): O. J. Ode

Journal: Journal of Advanced Scientific Research
ISSN 0976-9595

Volume: 2;
Issue: 3;
Start page: 66;
Date: 2011;
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Keywords: Cassia singueana | Indomethacin | Anti-ulcer | Preventive index | Stomach ulcer | Histopathology

ABSTRACT
The antiulcer activities of the methanolic extract of Cassia singueana leaves were evaluated using indomethacin-induced gastric ulcer model in rats. The extract was prepared by cold marceration in 80% methanol at 370C with intermittent shaking for 48 h. A yield of 12.6% w/w dry extract was obtained. The extract was safe, up to a dose of 4000 mg/kg given per os did not cause mortality in the rats. The extract at 250 and 750 mg/kg produced significant (p
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