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ANTIULCER ACTIVITY OF AQUEOUS EXTRACT OF FRESH LEAF OF BRASSICA OLERACEAE LINN. VAR. ACEPHALA (D.C) ALEF) (BRASSICACEAE)

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Author(s): Agbaje, Esther Oluwatoyin | Okpara, Chioma Sonia

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 8;
Start page: 107;
Date: 2013;
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Keywords: Gastric ulcer | Duodenal ulcer | Ulcerogen | Brassica oleraceae Extract | Rat | Phytoconstituents.

ABSTRACT
Brassica oleraceae (BOL) is the common cabbage and a familiar garden plant, widely used as spice all over the world. Cabbage is an excellent source of Vitamin C and has been widely employed locally to treat acute inflammation and peptic ulcers. The present study aimed at evaluating the anti¬ulcer activity of Brassica oleraceae, while identifying the phytoconstituents responsible for the observed effects and exploring some of the possible mechanisms of its anti¬ulcer activity, using standard laboratory procedures. Doses of 100, 300 and 750 mg / kg of Brassica oleraceae were separately administered to groups of overnight fasted rats, with appropriate standard drugs using Ethanol / HCl, Indomethacin and Cysteamine models to explore anti¬ulcer property of BOL on the stomach and duodenum respectively. The extract in a dose¬ dependent fashion, offered better protection against the ulcerogens in the gastric ulcer models, when compared with the positive control groups. However, the smallest dose of 100 mg / kg recorded the highest percentage protection in the cysteamine group. Up to 1200 mg / kg i.p and 10,000 mg / kg oral doses of Brassica oleraceae did not produce any mortality in mice. Phytochemical constituents identified included alkaloids, tannins, cardiac glycosides, flavonoids, phlobatannins, anthraquinones and saponins. The pH was 8.5. The present study has validated the local use of Brassica oleraceae in the treatment of peptic ulcer and the speculated mechanisms of action could be through acid neutralization, cytoprotection and antioxidation by flavonoids.
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