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Antiurolithiatic activity of Dichrostachys cinerea (L.) Wight&Arn root extract

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Author(s): S. Jayakumari*, J. Anbu, and V. Ravichandran

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 4;
Start page: 1206;
Date: 2011;
Original page

Keywords: Antiurolithiatic | Ethylene glycol | Dichrostachys cinerea

ABSTRACT
Dichrostachys cinerea (L.) Wight & Arn (Mimosaceae) is commonly known as Vidathalai and used as phytotherapeutic agent. Tender shoots of the plant bruised and applied to the eyes in case of ophthalmia. The root is astringent and used in rheumatism, urinary calculi and renal troubles. The effect of the ethanolic extract of the root of Dichrostachys cinerea (L.) was studied for its anti-urolithiatic effect at 200mg/k and 400mg/kg dose levels in male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with ethanolic extract of the plant significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. Both the dose levels showed significant urolithiatic activity. The results of the present study supports folklore claim of Dichrostachys cinerea in urinary calculi
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