Academic Journals Database
Disseminating quality controlled scientific knowledge

Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats

ADD TO MY LIST
 
Author(s): Ashok Purnima | Koti Basavaraj | Vishwanathswamy A.H.M.

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 42;
Issue: 6;
Start page: 380;
Date: 2010;
Original page

Keywords: Antiurolithiatic activity | BUN | creatinine | Mimusops elengi

ABSTRACT
Objective: To evaluate the potential of Mimusops elengi in the treatment of renal calculi. Materials and Methods: Petroleum ether, chloroform, and alcohol extracts of Mimusops elengi bark were evaluated for antiurolithiatic and antioxidant activity in male albino Wistar rats. Ethylene glycol (0.75%) in drinking water was fed to all the groups (Groups II-IX) except normal control (Group I) for 28 days to induce urolithiasis for curative (CR) and preventive (PR) regimen. Groups IV, V, and VI served as CR, and groups VII, VIII, and IX as PR were treated with different extracts of M. elengi bark. Groups I, II, and III served as normal control, positive control (hyperurolithiatic), and standard (cystone 750 mg/kg), respectively. Oxalate, calcium, and phosphate were monitored in the urine and kidney. Serum BUN, creatinine, and uric acid were also recorded. In vivo antioxidant parameters such as lipid peroxidation (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were also monitored. Results: All the extracts of M. elengi were safe orally and exhibited no gross behavioral changes in the rats. In hypercalculi animals, the oxalate, calcium, and phosphate excretion grossly increased. However, the increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly (P < 0.001) lowered by curative and preventive treatment with alcohol extract (AlE) of M. elengi. It was also observed that alcoholic extract of M. elengi produced significant (P < 0.001) decrease in MDA, and increased GSH, SOD, and CAT. These results confirm that AlE of M. elengi possess potent antiurolithiatic activity. Conclusion: The results obtained suggest potential usefulness of the AlE of M. elengi bark as an antiurolithiatic agent.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?