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Antiviral Activity and Constituents of the Nepalese Medicinal Plant Astilbe rivularis

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Author(s): Meena Rajbhandari | Michael Lalk | Renate Mentel | Ulrike Lindequist

Journal: Records of Natural Products
ISSN 1307-6167

Volume: 5;
Issue: 2;
Start page: 138;
Date: 2011;
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Keywords: Astilbe rivularis | antiviral | arbutin | bergenin | dimer of bergenin.

ABSTRACT
During the screening of Nepalese ethnomedicinal plants for antiviral activities, Astilbe rivularis Buch.-Ham. , Saxifragaceae, was identified as a promising species. Bioassay-guided fractionation led to the isolation of arbutin, bergenin and a bergenin derivative. The structures were established by NMR studies. Except bergenin, the two compounds were found in this plant for the first time. A dimer of bergenin has not been described as a natural product before. The compounds showed in vitro antiviral activity against herpes simplex virus type-1 in non cytotoxic concentrations.
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