Academic Journals Database
Disseminating quality controlled scientific knowledge

Antiviral effect of Anthocleista nobilis root extract on the liver homogenate indices of poultry fowls infected with Newcastle Disease Virus (NDV)

ADD TO MY LIST
 
Author(s): Ayodele P. O, | Okonko I. O, | Chukwuka K. S, | Odu N. N | Michael V. I

Journal: Research Opinions in Animal & Veterinary Sciences
ISSN 2221-1896

Volume: 1;
Issue: 8;
Start page: 546;
Date: 2011;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Anthocleista nobilis | Antiviral Effect | Liver Homogenate Indices | Fowls | Ulceration

ABSTRACT
This study reports the preliminary investigation of the antiviral effect of Anthocleista nobilis root extract on the liver homogenate indices of poultry fowls treated for Newcastle Disease (ND). Eighteen (18) weeks-old fowls were used for this study. These were divided into 3 groups, A (infected and with treatment), B (infected and without treatment) and C (control). Groups A and B were challenged with Newcastle disease virus (NDV). Group A and C were given ethanolic root extract of A. nobilis orally at intervals of 6 h at 0.5 mg per 100 g of body weight for 28 days. All the fowls were also given tetracycline antibiotic to eliminate bacterial infections. The average body weight and the temperature were monitored. The cytological examination of the fowls in group B showed that there was ulceration in the intestinal lining. There was increase in the average body temperature of the fowls in group B (41.9+0.2oC). There was also a drop in their average body weight from 510+0.2g to 508+0.2g between days 1 to 6. The liver homogenate values obtained before challenging the fowls with NDV indicated that all the fowls were healthy and no physiological abnormalities were traced in them. The values obtained at day 7 of treatment with the extract indicated a drastic drop in the mean total protein and protein fractions of the fowls in group B (8.20g/l, 4.30g/l, and 3.90g/l), followed by those of group A (7.15g/l, 2.95g/l, and 4.20g/l) and C tended toward normal ranges (51.48g/l, 22.83g/l, and 28.65g/l). At day 28, the result showed that fowls in group A tended toward normal mean values of total protein (29.35g/l), albumin (11.70g/l), and globulin (17.65g/l), followed by group C total protein (52.80g/l), albumin (24.10g/l), and globulin (28.70g/l). The study showed physiological evidence that the treatment of ND with the extract is equally effective at day 28. After day 28, there were no survivors among the fowls in group B. No ulceration was observed in group A fowls. The study also showed a drastic drop in liver homogenate indices of group B fowls and those of group A. Fowls in group C were with normal ranges at day 7. This suggests that the extract of A. nobilis was able to either prevent the multiplication of NDV or ameliorate the toxic effect leading to ulceration. These positives changes observed in group A is thus physiological evidence that the treatment of ND with the ethanolic root extract of A. nobilis is effective. With these physiological evidences, it can be concluded that the extract was effective to impact immunity in fowls infected with NDV. Thus, there is need to create awareness among farmers and poultry dealers to encourage them to use the ethanolic root extract of A. nobilis for the treatment of ND. The extract was able to correct the physiological alteration (liver homogenate indices) associated with Newcastle disease.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?