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Application of new original ointments for treatment of burns with experimental pseudomonas infection

Author(s): Shub G. М. | Alipov V. V. | Lebedev М. S. | Dobreikin Е.А. | Alipov N. V. | Pronina E.A. | Raikova S. V. | Shapoval O. G.

Journal: Saratov Journal of Medical Scientific Research
ISSN 1995-0039

Volume: 7;
Issue: 2;
Start page: 523;
Date: 2011;
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Keywords: burns | local treatment | Pseudomonas aeruginosa

The research goal is to assess the efficacy of treatment with two new original ointments for burns with experimental pseudomonas infection. Burns have been caused by laser to three groups of white rats (20 animals in each group). In 3 days the wounds were infected with clinical strain of Pseudomonas aeruginosa. The wounds of the first group of rats were treated with ointments № 1, the wounds of the second group of rats — with ointments № 2. The third group did not receive any treatment. In 3, 10 and 14 days period the number of microbial cells in purulent discharge was studied. Then they were grown on meat-peptone agar. The number of colonies was counted. The number of cells in purulent discharge of treated wounds was less, than it was in purulent discharge of untreated wounds. The number of cells in purulent discharge of treated with ointments №1 wounds was higher, than it was in purulent discharge of treated with ointments №2 wounds. The article concludes that the local antimicrobial effect of both ointments is explained by their main components — some essential volatile oils and chloramphenicol
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