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Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates

Author(s): Nury E. Vargas-Alejo | Edgar A. Reyes-Montaño | Leonardo Lareo

Journal: Universitas Scientiarum
ISSN 0122-7483

Volume: 15;
Issue: 3;
Start page: 194;
Date: 2010;
Original page

Keywords: evolution in gene families | phylogenetic inference of ML and By | iGluR | AMPA | KA | NMDA

In silico approach to the evolution of ionotropic glutamate receptor gene family in four primate species. Man as a species has a brainunique in analysis capabilities due to its structure and organizational patterns that are presumably the basis of intelligence and the ability tomanipulate the environment. Additionally, the development and evolution of the brain respond underlying genetic processes. Objective. Topresent an approach to the evolutionary process of the iGluR with the maximum likelihood (ML) and Bayesian (By) phylogenetic analysismethods. Materials and methods. we used in silico methods to propose a model of molecular evolution and to do a qualitative recognitionof synteny blocks for these genes in different species of primates (chimpanzee, orangutan, rhesus monkey and man). Results. Glutamateis the main neurotransmitter and plays an important role in neuronal plasticity and neurotoxicity. Neurotransmission via glutamate ismediated by ionotropic glutamate receptors (iGluR) NMDA type and non-NMDA type (AMPA and KA). For every phylogeneticinference, we confirmed that the iGluRs of mammals could have evolved from a primitive signaling mechanism, thus explaining similarclusters between some species of primates and rodents. Conclusion. The NR-2 sequences have been exposed to a purifying selection, andthe neutral level of divergence is faster in primates than in rodents, however further studies are needed to confirm these theories of evolution.
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