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Aqueous Extract of Potato (Solanum tuberosum) Modulates Cadmium-induced Liver Damage in Female Wistar Rats

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Author(s): Akeem O. Lawal | Ebenezer O. Farombi | Adetola F. Lawal

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 7;
Issue: 5;
Start page: 599;
Date: 2011;
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Keywords: lipid peroxidation | liver | Cadmium | aqueous extract | potato

ABSTRACT
Cadmium (Cd) is an environmental and industrial pollutant known to be highly toxic to large number of tissues in the body. In this study, the protective effects of aqueous extract of potato (Solanum tuberosum) against the hepatotoxic effect of Cadmium (Cd) were investigated in a set of female Wistar rats. The rats were given oral administrations of potato extract for 3 weeks at a dose of 250 mg kg-1 body weight prior to one week intraperitoneal exposure to 4 mg kg-1 Cadmium (Cd) as Cadmium Chloride (CdCl2). Liver damage were monitored using markers of hepatocellular injury such as serum (GOT, Glutamate Oxaloacetate Transaminase; GPT, Glutamate Pyruvate Transaminase; ? GT, Gamma-Glutamyl Transpeptidase and ALP, Alkaline Phosphatase). The levels of reduced glutathione (GSH), GST activity, lipid peroxidation and the expressions of HO-1 and NQO1 were also determined in order to evaluate the antioxidant status of the liver after Cd exposure. The results show that the presence of aqueous extract of Solanum tuberosum significantly reduced the activities of all the serum enzymes in the presence of Cd. The level of GSH and the activity of GST were also significantly increased in the presence of the extract plus Cd when compared with rats exposed to Cd alone. The extract also attenuates lipid peroxidation induced by Cd indicating decrease oxidative damage. Western blot results show addictive effect of the extract and Cd on the expressions of HO-1 and NQO1. Taken together, the presence work shows that aqueous extract of Solanum tuberosum contains active agents that are potent in preventing Cd-induced liver damage in exposed rats.
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