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Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats

Author(s): Aloisi Anna | Ceccarelli Ilaria | Fiorenzani Paolo | Maddalena Melinda | Rossi Alessandra | Tomei Valentina | Sorda Giuseppina | Danielli Barbara | Rovini Michele | Cappelli Andrea | Anzini Maurizio | Giordano Antonio

Journal: Molecular Pain
ISSN 1744-8069

Volume: 6;
Issue: 1;
Start page: 69;
Date: 2010;
Original page

Abstract Background The steroid hormone testosterone has been found to be greatly reduced by opioids in different experimental and clinical conditions. The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis. Testosterone was determined in the plasma and in the brain, morphine was assayed in the plasma. Results In the morphine-treated rats, there were increases of 5-alpha reductase mRNA expression in the liver and aromatase mRNA expression in the brain and gonads. Morphine was detected in the blood of all morphine-treated rats even though there were no clear analgesic affects in the formalin-treated animals three hours after treatment. Testosterone was greatly reduced in the plasma and brain in morphine-treated subjects. Conclusions It appears that morphine administration can induce long-lasting genomic effects in different body areas which contribute to the strong central and peripheral testosterone levels. These changes were not always accompanied by behavioral modifications.
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