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ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons

Author(s): Molliver Derek | Immke David | Fierro Leonardo | Paré Michel | Rice Frank | McCleskey Edwin

Journal: Molecular Pain
ISSN 1744-8069

Volume: 1;
Issue: 1;
Start page: 35;
Date: 2005;
Original page

Abstract Background ASIC3, the most sensitive of the acid-sensing ion channels, depolarizes certain rat sensory neurons when lactic acid appears in the extracellular medium. Two functions have been proposed for it: 1) ASIC3 might trigger ischemic pain in heart and muscle; 2) it might contribute to some forms of touch mechanosensation. Here, we used immunocytochemistry, retrograde labelling, and electrophysiology to ask whether the distribution of ASIC3 in rat sensory neurons is consistent with either of these hypotheses. Results Less than half (40%) of dorsal root ganglion sensory neurons react with anti-ASIC3, and the population is heterogeneous. They vary widely in cell diameter and express different growth factor receptors: 68% express TrkA, the receptor for nerve growth factor, and 25% express TrkC, the NT3 growth factor receptor. Consistent with a role in muscle nociception, small (

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