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Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil

Author(s): Castello-Branco Luiz RR | Ortigão-de-Sampaio Maria Beatriz

Journal: Memórias do Instituto Oswaldo Cruz
ISSN 0074-0276

Volume: 95;
Issue: suppl.1;
Start page: 171;
Date: 2000;
Original page

Keywords: gastrointestinal immunology | human immunodeficiency virus-1 infection | nutrition | mucosal immunology

Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.
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