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Assessment of coronary atherosclerosis progression in patients with five year history of myocardial infarction depending on the statin therapy compliance

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Author(s): A.I. Chesnikova | V.A. Safronenko | A.V. Hripun

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 8;
Issue: 6;
Start page: 772;
Date: 2012;
Original page

Keywords: myocardial infarction | coronary angiography | statin therapy compliance | atherosclerosis progression

ABSTRACT
Aim. To study the coronary atherosclerosis progression in patients with 5-year history of myocardial infarction (MI) depending on the statin therapy compliance.Material and methods. Patients (n=31) with a five year history of MI were involved into the study. Patients were divided into two groups depending on the statin therapy compliance during 5 years after MI: group 1 — patients with high compliance, group 2 — patients with low compliance. Assessment of the coronary angiography and lipid profile was performed first time in 2005–2006 during hospital treatment for MI and after 5 years again.Results. Increase in the proportion of patients with two and three coronary vessel disease was found after 5 years of observation, despite the high rate of percutaneous coronary intervention (77.4%) and hypolipidemic therapy. Hemodynamically significant restenosis was found in 11.8% (group 1) and 21.4% (group 2) of patients. Target total cholesterol level was reached only in 42.9% and 11.8% of patients in group 1 and 2, respectively. The target level of low density cholesterol was achieved in no one patient.Conclusion. The findings suggest that in patients with 5-year history of MI coronary atherosclerosis progresses regardless of the statin therapy compliance.
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