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The assessment of effects of combined therapy with mildronate on lipid profile, inflammatory factors and endothelium function in patients with ischemic heart disease

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Author(s): I.V. Sergienko | V.V. Kukharchuk | S.A. Gabrusenko | V.V. Malakhov | V. P. Masenko | M. I. Tripoten | T.V. Balahonova

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 3;
Issue: 3;
Start page: 10;
Date: 2007;
Original page

Keywords: metabolic corrector | lipid profile | inflammatory factors | mildronate | ischemic heart disease.

ABSTRACT
Aim. To study the effect of treatment with metabolic corrector mildronate on lipid profile, inflammatory factors and endothelium function in patients with ischemic heart disease (IHD).Material and methods. 60 patients with IHD (stable exertional angina, II-IV functional class) were included in to the study. They were split in two groups. Patients of the main group (n=30) were treated with mildronate (1000 mg per day during 3 months) combined with standard therapy. Patients of the second group (n=30) received the standard therapy only. Total cholesterol (TC), triglycerides (TG), cholesterol of low density lipoproteid (LDL-C), cholesterol of high density lipoproteid (HDL-C), aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), creatine kinase (CK), C-reactive protein (CRP), interleukin-6 (IL-6), lipoprotein (α) (Lp(α)), NO3 were determined. Besides endothelium dependent vasodilatation of brachial artery was studied.Results. TC, HDL-C and TG levels did not differ before and after treatment with mildronate, but LDL-C level significantly reduced (from 3.06±1.32 to 2.7±1.0 mmol/l, p
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