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Assessment of Oxidative Stress Markers Related to Atherosclerosis in Pre-Hypertensive Women

Author(s): Farshad Amirkhizi | Fereydoun Siassi | Mahmoud Djalali | Sara Minaie | Ahmad Reza Dorosty

Journal: Journal of Tehran University Heart Center
ISSN 1735-8620

Volume: 2;
Issue: 3;
Start page: 137;
Date: 2007;
Original page

Keywords: Pre-hypertension | Oxidative stress | Atherosclerosis | Women

"nBackground: Lipid peroxidation is a free radical-generating process which occurs on every membranous structure of the cell. Free radicals are known to be involved in a number of human pathologies including atherosclerosis. The purpose of this cross-sectional study was to examine the association between pre-hypertension status and oxidative stress markers [total antioxidant capacity (TAC) and malonedialdehyde (MDA) levels] in a random sample of cardiovascular disease-free women. "nMethods: In this study, 160 women of 20-45 years of age were randomly selected. General information data were gathered from each sample using questionnaires and face-to-face interviews. Blood pressure (BP) was measured for each subject. Body weight, height, and waist and hip circumferences were measured and body mass index (BMI) "nand waist-to-hip ratio (WHR) were calculated for each subject. Venous blood samples were drawn from the subjects, and plasma was separated. In this study, the oxidative stress status was assessed by measuring the concentrations of plasma MDA and TAC levels. "nResults: Our results show that both systolic and diastolic blood pressures were inversely correlated with TAC (p

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