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Assessment of Palmitoyl and Sulphate Conjugated Glycol Chitosan for Development of Polymeric Micelles

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Author(s): Ikram Ullah Khan | Gohar Ayub | Nazar M. Ranjha

Journal: BioImpacts
ISSN 2228-5652

Volume: 3;
Issue: 2;
Start page: 97;
Date: 2013;
Original page

Keywords: Palmitoyl Glycol Chitosan Sulfate (PGCS) | Glycol Chitosan | Chlorosulfonic Acid | Palmitic Acid N- hydroxysuccinimde Ester | Polymeric Micelles

ABSTRACT
Introduction: Amphiphilic copolymers are capable of forming core shell-like structures at the critical micellar concentration (CMC); hence, they can serve as drug carriers. Thus, in the present work, polymeric micelles based on novel chitosan derivative were synthesized. Methods: Block copolymer of palmitoyl glycol chitosan sulfate (PGCS) was prepared by grafting palmitoyl and sulfate groups serving as hydrophobic and hydrophilic fractions, respectively. Then, fourier transform infrared spectra (FTIR) and spectral changes in iodine/iodide mixture were carried out. Results: FTIR studies confirmed the formation of palmitoyl glycol chitosan sulfate (PGCS) and spectral changes in iodine/iodide mixture indicated CMC which lies in the range of 0.003-0.2 mg/ml. Conclusion: Therefore, our study indicated that polymeric micelles based on palmitoyl glycol chitosan sulphate could be used as a prospective carrier for water insoluble drugs.
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