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Assessment of prolactin associated platelet activation in ischemic stroke

Author(s): Ayşegül Akagündüz Ege | Şule Bilen | Fikri Ak

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 3;
Issue: 1;
Start page: 1;
Date: 2012;
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Keywords: Ischemic stroke | prolactin | mean platelet volume | platelet count

Objectives: We aimed to investigate whether there wereany relations between prolactin levels, prolactin associatedplatelet activation and ischemic stroke, and whetherthey had role in etiology of ischemic stroke.Materials and methods: Totally 57 patients with thediagnosis of acute ischemic stroke and 43 age and sexmatched controls with no history of ischemic vascular diseaseswere included in the study. Prolactin levels, meanplatelet volume (MPV) a marker of platelet activation, andplatelet count, of the patients, after 12 hours of fasting,compared with the measurements of control group.Results: Patients had significantly higher prolactin levels.A correlation between prolactin levels and early measurementsof MPV was not detected. While there was no differencein terms of MPV, the platelet count was significantlyhigher in the patient group.Conclusions: In the present study, the existence of aneffect of prolactin on the mean platelet volume, or a relationshipbetween early ischemic stroke and MPV couldnot be shown. However, in ischemic stroke patients, inearly phase, presence of higher levels of prolactin andplatelet count may be meaningful in etiology of ischemicevents. Besides, presence of higher prolactin levels inearly phase of ischemic stroke may lead to consider thepotential role of prolactin elevation in ischemic strokepathogenesis. J Clin Exp Invest 2012; 3(1): 1-6
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