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Assessment of toxicity of chemicals in workers of rubber industry

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Author(s): Ram Singh, Sachin Kumar and Sunita Sharma*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3229;
Date: 2011;
Original page

Keywords: Biomonitoring | Rubber industry | Micronucleus | Lactate dehydrogenase (LDH) | Blood glutathione (GSH).

ABSTRACT
Various chemicals like polycyclic aromatic hydrocarbons [PAH], N-nitrosamines, 1, 3-butadiene, acetonitrile, styrene, vinyl chloride, mineral oils, othervolatile organic compounds, etc. are generally used in manufacturing of rubber and have shown hazardous effects in human beings upon regular exposure. In viewof the above, a study was carried out to determine variation in Hb%, TLC and differential leukocyte count, level of oxidative stress by estimating GSHconcentration, genotoxic risk by studying micronuclei in lymphocytes and effect of compounds on various organs by studying the level of expression of LDHisozymes. The blood samples were collected from 20 rubber industry workers for each group and 20 healthy workers who served as control. A decreasedconcentration of Hb% and TLC was observed in workers with the increase in time of exposure, albeit in normal range. There was significant decline in theneutrophil, eosinophil, lymphocyte and monocyte counts in workers who were exposed to 4-6 years. The decreased levels of GSH concentration signifyinduction of oxidative stress in workers. The presence of micronuclei was observed in workers who were exposed to 4-6 years and confirm the genotoxic riskin the workers of them. The increased level of LDH expression (LDH 2, LDH 3, LDH 4 and LDH 5) indicated the injured cells of different tissues. Hence, itmay be concluded that the workers of rubber industry encounters injurious effect due to chemical compound exposure.
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