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Association between adiponectin level and residual insulin secretion in type 1 diabetes in children Związek stężenia adiponektyny z zachowaną insulinosekrecją w cukrzycy typu 1 u dzieci

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Author(s): Agnieszka Zmysłowska | Agnieszka Szadkowska | Beata Mianowska | Iwona Pietrzak | Wojciech Młynarski

Journal: Przegląd Pediatryczny
ISSN 0137-723X

Volume: 41;
Issue: 2;
Start page: 69;
Date: 2011;
Original page

Keywords: type 1 diabetes | children | adiponectin | C-peptide

ABSTRACT
Introduction: In the pathogenesis of type 1 diabetes mellitus (T1DM), apart from insulin secretion deficiency, insulin resistance is also observed. Insulin resistance is conditioned by genetic background and environmental factors. We discuss one of the most important mediators associated with the metabolism of adipose tissue adiponectin. Aim of the study was to evaluate adiponectin level and the association between adiponectin level and C-peptidelevel, as a residual insulin secretion factor, in children with T1DM. Material and methods: The study group comprised 197 type 1 diabetic children, aged 1-18 years (average10.4), 84 girls and 113 boys, and 47 healthy children, aged 10.2, 17 girls and 30 boys as a control group. Plasma adiponectin and C-peptide levels were detected by radioimmunoassay at diagnosis, after 6 months andafter 2, 3 and 4 years of disease. Results: We observed a gradual decrease in adiponectin level in the course of T1DM (p

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Tangokurs Rapperswil-Jona

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