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Association between C-reactive protein, carotid intima-media thickness and P-wave dispersion in obese premenopausal women: an observational study

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Author(s): Ufuk Özuğuz | Gökhan Ergün | Serhat Işık | Ferhat Gökay | Yasemin Tütüncü | Gülhan Akbaba | Dilek Berker | Serdar Güler

Journal: Anadolu Kardiyoloji Dergisi
ISSN 1302-8723

Volume: 12;
Issue: 1;
Start page: 40;
Date: 2012;
Original page

Keywords: Obesity | subclinical inflammation | P-wave dispersion | atherosclerosis | regression analysis

ABSTRACT
Objective: The aim of the present study was to evaluate P-wave dispersion (PWD) in obese women, and to investigate the relationship between P-wave measurements, high sensitive C-reactive protein (hsCRP), carotid intima-media thickness (CIMT) and echocardiographic findings. Methods: Forty-four patients with obese premenopausal women and 30 females with normal weight were enrolled this cross sectional, observational study. Results of anthropometric measurements, laboratory assays, electrocardiographic and echocardiographic findings were recorded for each participant. Student t, Mann-Whitney U and Pearson Chi-square tests, and Spearman correlation analysis were used for statistical analysis. Multiple regression analysis was used to identify independent factors associated with PWD development.Results: The obese group had significantly higher values for PWD (41.8±11.8 ms vs. 28.5±9.3ms; p

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