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The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population

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Author(s): HR Khorram Khorshid | E Gozalpour | K Kamali | M Ohadi | M Karimloo | MH Shahhosseiny

Journal: Iranian Red Crescent Medical Journal
ISSN 1561-4395

Volume: 13;
Issue: 4;
Start page: 256;
Date: 2011;
Original page

Keywords: Alzheimer’s disease | Genetic association | Apolipoprotein E | Polymorphism | ATP-binding cassette transporter A1 | Iran

ABSTRACT
Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’sdisease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette transporter A1 (ABCA1)gene on chromosome 9, which has been known by genome-wide AD linkage study, has an important role incellular cholesterol efflux. This study determines the association between sporadic AD and the human ABCA1and APOE gene polymorphisms in Iranian population.Methods: 154 AD cases and 162 control subjects from Iranian population were genotyped for APOE genotypesand ABCA1 polymorphism (R219K).Results: The frequency of ε2ε3 genotype was higher in control subjects comparing AD patients but was notsignificant (13% versus 5.8%) and ε3ε4 genotype frequency was significantly higher in AD cases comparing withcontrol subjects. APOE-ε2 allele frequency in cases was lower than control subjects but this difference was notsignificant (4.5% versus 8%). Individuals carrying ε4 allele, developed AD 6.5 times more than non-carriers(OR=6.52, 95%CI=2.63-16.17). There was no significant association between ABCA1 polymorphism and AD.Conclusion: Unlike other studies, R219K polymorphism was not dependent on gender and APOE-ε4 allele andthere was no association between APOE and ABCA1 in AD patients compared to controls.
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