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Association of Chronic Urticaria and / or Angioedema with Thyroid Autoimmunity

Author(s): R Sherkat | A Khereadmand | M Amini | A Asilian

Journal: Journal of Shahid Sadoughi University of Medical Sciences
ISSN 2228-5741

Volume: 12;
Issue: 3;
Start page: 51;
Date: 2004;
Original page

Keywords: Chronic Urticaria | Chronic Angioedema | Autoimmunity | Anti Thyroperoxidase | Anti Thyroglobulin.

Introduction: Auto – immune disorders have been implicated as a cause for chronic uricaria and/ or angioedema and thyroid autoimmunity has been increasingly introduced to be associated with that. This study explores the association of thyroid autoimmunity with chronic urticaria and / or angioedema in Isfahani patients. Methods: Anti – thyroperoxidase (Ani – TPO) and anti – thyroglobulin (Anti – Tg) antibodies, T4 and TSH were detected in 57 patients with chronic urticaria and / or angioedema and were compared with that of normal subjects without chronic urticaria or other autoimmune diseases. Results: Anti – TPO and Anti – Tg antibodies had been increased in 26 (45.6%) and 28 (49%) of patients in case group, as compared to 8 (13.2%) and 10 (16.7%) of subjects in control group, respectively. In total, raised titers of thyroid autoantibodies were found in 34 (60%) and 12 (20%) of subjects in case and control groups, respectively. Conclusion: Considering the high prevalence of thyroid autoantibodies in patients with chronic urticaria and / or angioedema, these antibodies should be detected in affected patients, specially in young and middle– aged women.

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