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Association of G/A Polymorphism, rs266882, in AREI Region of the Prostate-Specific Antigen Gene with Prostate Cancer Risk and Clinicopathological Features

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Author(s): Mohammad Samzadeh | Mandana Hasanzad | Seyed Hamid Jamaldini | Ali Akbar Haghdoost | Mahdi Afshari | Seyed Amir Mohsen Ziaee

Journal: Urology Journal
ISSN 1735-1308

Volume: 9;
Issue: 4;
Start page: 691;
Date: 2012;
Original page

Keywords: prostate cancer | benign prostatic hyperplasia | prostate-specific antigen | genetics | polymorphism

ABSTRACT
Purpose: To determine the association of prostate-specific antigen (PSA) 158A/G polymorphism with clinicopathologic characteristics of the disease and prostate cancer (PCa) risk.Materials and Methods: Two hundred and six subjects, including 95 patients with PCa and 111 subjects with benign prostatic hyperplasia (BPH), were recruited in this study. Genotyping was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method. Results: Presence of GG genotype significantly increased the risk of PCa more than 2-fold compared to AG genotype (adjusted odds ratio = 2.4; P = .03). The percentages of G alleles of polymorphisms in patients with PCa were more than that in ones with BPH (odds ratio = 1.2; P = .7). Conclusion: The GG genotype of PSA 158A/G polymorphism is a predisposing factor for PCa. But no association was observed between alleles and grade, stage, or age of diagnosis. Similarly, the rs266882 polymorphism was not associated with PSA plasma levels.
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