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Association of Haptoglobin Phenotypes with Serum Levels of IgE and IgA in Allergic Rhinitis Patients

Author(s): Hossein Ali Khazaei | Alireza Nakhaei | Gholam Ali Dashti | Mehdi Mohammadi | Fariba Hejazenia | Noura Mehrangeez | Amin Khazaei

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 9;
Issue: 4;
Start page: 254;
Date: 2012;
Original page

Keywords: Allergic Rhinitis | Haptoglobin | IgA | IgE

Background: Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. Objective: To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels in patients suffering from AR in comparison with healthy individuals. Methods: Two hundred and forty patients and 240 healthy individual entered in this case-control study. Serum levels of IgE and IgA were measured and haptoglobulin phenotypes were determined by electrophoresis. The results were evaluated by χ2 statistical test using SPSS software. Results: Serum electrophoresis showed that the distribution of haptoglobin phenotypes of Hp1-1, Hp2-1 and Hp2-2 among 240 patients were 11.3%, 37.9% and 50.8%, respectively. The distribution of different haptoglobin phenotypes in healthy controls were 88.7%, 36.6% and 54.7%, respectively. However, the difference between patients and controls was not statistically significant (p=0.136). The mean of IgE level was significantly higher in patients than controls in association with all three phenotypes (p

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