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The Association of Helicobacter pylori Infection with Hashimoto's Thyroiditis

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Author(s): Rokhsareh Aghili | Faria Jafarzadeh | Raheb Ghorbani | Mohammad Ebrahim Khamseh | Maryam Alsadat Salami | Mojtaba Malek

Journal: Acta Medica Iranica
ISSN 0044-6025

Volume: 51;
Issue: 5;
Start page: 293;
Date: 2013;
Original page

Keywords: Autoimmune Thyroid Disease | Hashimoto Thyroiditis | Helicobacter Pylori

ABSTRACT
Autoimmune thyroid diseases (ATD) are multifactorial conditions that result from genetic predisposition in combination with environmental risk factors. Helicobacter pylori infection as an environmental risk factor has been proposed to imitate the antigenic components of the thyroid cell membrane and may play a leading role in the onset of the autoimmune diseases, such as Hashimoto thyroiditis. The aim of this study was to investigate the association between Helicobacter pylori (HP) infection and Hashimoto's thyroiditis (HT). The participants in this case-control study included 43 patients affected by Hashimoto's thyroiditis, and 40 healthy individuals without history of autoimmune disease as the control group. Anti HP IgG and anti-TPO antibodies were determined using ELISA method. Results were considered positive when the IgG anti-HP value was higher than 30 IU/ml and the anti-TPO autoantibody value was higher than 75 IU/ml. The mean TSH level was 18.3±16.8 IU/ml for patients and 2.8±1.2 IU/ml for the control group (P
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