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Association of KIR3DS1+HLA-B Bw4Ile80 Combination with Susceptibility to Tuberculosis in Lur Population of Iran

Author(s): Farhad Shahsavar | Tahereh Mousavi | Alireza Azargoon | Kobra Entezami

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 9;
Issue: 1;
Start page: 39;
Date: 2012;
Original page

Keywords: HLA | KIR | NK Cells | Tuberculosis

Background: Natural killer (NK) cells are the effector cells of innate immunity thatrespond to infection and tumor. Interactions between killer cell immunoglobulin likereceptors (KIR) and human leukocyte antigen (HLA) class I molecules regulate NKcells responses to eliminate infected and transformed cells. Objective: To investigatethe impact of KIR genes, HLA ligand genes, and KIR-HLA combinations onsusceptibility to tuberculosis (TB) in Lur population of Iran. Methods: The genomicDNA of 50 patients with TB from Lorestan province of Iran was genotyped for sixteenKIR genes and their five major HLA class I ligands were determined by a polymerasechain reaction-sequence-specific primers (PCR-SSP) assay. The results were comparedwith those of 200 healthy unrelated Iranian individuals. Results: In Lur population ofIran, a significant decrease in frequency of KIR3DS1 was found in TB patientscompared to control group (24% vs. 44.5%, OR=0.394, CI=0.194-0.798, p=0.013).Also, among the three activating genes that may use HLA class I molecules as theirligands, a significant decrease was shown in frequency of KIR3DS1 with HLA-BBw4Ile80 ligand in TB patients compared to control group (4% vs. 23%, OR=0.14,CI=0.033-0.596, p=0.004). Conclusion: These findings imply a genetic imbalancebetween activating and inhibitory KIR genes and KIR-HLA combinations in Lur TBpatients. Low level of activating KIR3DS1 and its combination with HLA-B Bw4Ile80ligand might have an influence on the susceptibility to TB in Lur population of Iran.
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