Academic Journals Database
Disseminating quality controlled scientific knowledge

Association of Obesity and Diabetes with Serum Prostate-Specific Antigen Levels in Japanese Males

ADD TO MY LIST
 
Author(s): MARIKO NAITO | YATAMI ASAI | ATSUYOSHI MORI | YUKO FUKADA | MAYUMI KUWABARA | SHIRO KATASE | ASAHI HISHIDA | EMI MORITA | SAYO KAWAI | RIEKO OKADA | KAZUKO NISHIO | AKIKO TAMAKOSHI | KENJI WAKAI | NOBUYUKI HAMAJIMA

Journal: Nagoya Journal of Medical Science
ISSN 0027-7622

Volume: 74;
Issue: 3,4;
Start page: 285;
Date: 2012;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Prostate-specific antigen | Diabetes mellitus | Obesity | Body mass index | Epidemiology

ABSTRACT
Patients with diabetes have been reported to be at an increased risk for cancers of the pancreas, liver, and colon; however, recent studies have suggested that men with diabetes are at a decreased risk for prostate cancer. Previous studies have found that obese men have lower serum prostate-specific antigen (PSA) concentrations than do non-obese men. Further understanding of how obesity and diabetes affect the PSA concentration may improve our ability to detect clinically relevant prostate tumors. This study examined the relationships among serum PSA level, obesity, and diabetes in apparently healthy Japanese males. We analyzed the baseline data from 2,172 Japanese males (age, 56.8 ± 6.1 years [mean ± SD]) who participated in the Japan Multi-Institutional Collaborative Cohort Study. Diabetes was defined as the presence of both a hemoglobin A1c (JDS) of ≥6.1% and a fasting plasma glucose level of ≥126 mg/dL, or a positive medical history. After adjusting for age, the PSA levels were elevated among males with a higher normal BMI (ranging from 23.0 to 24.9) and lowered among men with a BMI of ≥25.0. In the stratified analysis, these significant differences in BMI categories were absent among diabetics. The mean PSA levels were significantly lower in diabetics than in non-diabetics among subjects aged 60 and over. Our findings suggest that the pre-overweight men had increased PSA levels, and the diabetes was associated with a reduction of PSA levels in elderly.

Tango Rapperswil
Tango Rapperswil

     Affiliate Program