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The association study of gene polymorphism of vascular endothelial growth factor with diabetic retinopathy

Author(s): Dong-Hao Li | Li Hu | Wen-Zhi He | Hong-Hong Qiu | Yi-Yi Wen | Qian Yang

Journal: Guoji Yanke Zazhi
ISSN 1672-5123

Volume: 13;
Issue: 6;
Start page: 1106;
Date: 2013;
Original page

Keywords: vascular endothelial | growth factor | gene polymorphism | diabetic retinopathy

AIM:To investigate the correlation of vascular endothelial factor(VEGF)I/D gene polymorphism with diabetic retinopathy(DR)in type 2 diabetes mellitus. METHODS: The 91 patients with diabetes and 30 control cases which VEGF I/D genotypes and VEGF level were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).RESULTS: The DD genotype frequencies were significantly higher in NPDR and PDR groups than in groups of NDR and control(P
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