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ASSOCIATION OF VARIOUS GENETIC MARKERS IN PSORIASIS AND VITILIGO

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Author(s): Vedangi Aaren*, G Paddaiah, G Sudhakar and M Ramesh

Journal: International Journal of Bioassays
ISSN 2278-778X

Volume: 2;
Issue: 7;
Start page: 1062;
Date: 2013;

Keywords: Genetic markers | Psoriasis | Vitiligo | Red Cell Enzymes | Plasma Proteins.

ABSTRACT
Psoriasis and Vitiligo are the skin disorders which are mediated by immunologically and inherited genetically. These are most predominant in the cases where the immune system sends faulty signals and by which the body produces an immune response against some of its own cells. Psoriasis occurs when skin cells grow too quickly. Where as in Vitiligo the immune system destroys pigmented making cells called melanocytes. This results in lesions formation and white patches of skin on different parts of the body. The present study undergone to determine whether the biochemical genetic marker phenotypes are predictive of Psoriasis and Vitiligo. Using biochemical techniques the association between Psoriasis and Vitiligo with Red cell enzymes like ESD, SOD, ACP1, GLO1 and Plasma proteins like HP, CP, ALB, GC, and TF have been extensively studied on 40 individuals of each disorder and 80 healthy controls. The results were compared with the healthy population series investigated for the same genetic markers. There was no significant association with any of the marker systems.
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