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Atenolol premedication in patients undergoing closed mitral commissurotomy.

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Author(s): Neema Praveen | Waiker Hemant

Journal: Annals of Cardiac Anaesthesia
ISSN 0971-9784

Volume: 6;
Issue: 1;
Start page: 42;
Date: 2003;

ABSTRACT
Perioperative tachycardia is common in patients undergoing surgery. In patients with mitral valve stenosis, the tachycardia can precipitate congestive heart failure and pulmonary oedema. Efficacy of atenolol premedication (0.5 mg/kg) for haemodynamic stability was assessed in 37 patients undergoing closed mitral commissurotomy (Group I) and compared with 43 patients who did not receive it (Group II). Patients with mild aortic regurgitation, atrial fibrillation, mild to moderate pulmonary artery hypertension or severe pulmonary artery hypertension without right ventricular failure were all included in the study. All patients were premedicated with tablet diazepam 0.1 mg/Kg, on the previous night and on the day of surgery and intramuscular morphine 0.1 mg/kg and glycopyrrolate 0.2 mg 45 min before surgery. In addition, in group I, atenolol 0.5 mg / kg was administered at night and 2 hours prior to surgery. Anaesthesia was induced with thiopental, morphine, oxygen and isoflurane. Tracheal intubation was facilitated by pancuronium bromide 0.12 mg/kg. Maintenance was with morphine, isoflurane and nitrous oxide in oxygen. The study was confined to the periods of maximal anaesthetic and surgical haemodynamic stress like laryngoscopy, intubation, surgical incision and commissurotomy. For all periods of haemodynamic stress, heart rate was significantly lower in group I, (p

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